{"_buckets": {"deposit": "48de3875-9bf4-4749-a6e6-a164a4eca3ff"}, "_deposit": {"created_by": 15, "id": "865", "owners": [15], "pid": {"revision_id": 0, "type": "depid", "value": "865"}, "status": "published"}, "_oai": {"id": "oai:iuhw.repo.nii.ac.jp:00000865", "sets": ["136"]}, "author_link": ["1896", "1897", "1898", "1899", "1867"], "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-10-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "52", "bibliographicPageStart": "46", "bibliographicVolumeNumber": "22", "bibliographic_titles": [{"bibliographic_title": "国際医療福祉大学学会誌"}, {"bibliographic_title": "Journal of the International University of Health and Welfare", "bibliographic_titleLang": "en"}]}]}, "item_10001_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Objectives: The purpose of the present study was to examine the reactivity and regioselectivity of ethyl benz[f]indole-2-carboxylate in electrophilic substitution.  We also attempted to synthesize a tryptamine analogue from a 3-formylated compound.\nMethods: For the formation of a carbon-carbon bond to give ethyl benz[f]indole-2-carboxylate, we examined two types of reactions: Friedel-Crafts acylation and formylation.\nResults: Friedel-Crafts acylation of the benz[f]indole gave 3-, 4- and 9-acetylated compounds without regioselectivity. On the other hand, formylation selectively gave a 3-formylated compound. Elongation of the 3-formylated compound followed by selective reduction afforded a 3-nitroethyl compound.\nConclusions: Benz[f]indoles are considered to have properties that reflect the hybridization of an indole and anthracene. Therefore, the reactive sites of benz[f]indoles in electrophilic substitution are believed to be the 3-, 4- and 9-positions.", "subitem_description_type": "Abstract"}]}, "item_10001_description_6": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "目的：ベンズ[ f ] インドール誘導体を対象として，その求電子置換反応を行うことにより，反応性と位置選択性の検討を目的とした．3 位への位置選択的炭素鎖導入後に，生理活性化合物を目指してトリプタミンアナローグの合成も行う．\n方法：炭素‒炭素結合の代表的な求電子置換反応であるFriedel-Crafts アシル化およびホルミル化を行った．得られた3‒ホルミル体から増炭・窒素官能基の導入を行い，トリプタミンアナローグの合成を検討した．\n結果：2 種の求電子置換反応の結果，アシル化では3 種の混合物（3，4，9 位）となり位置選択性はなく，ホルミル化では3 位への選択性が見られた．これらの結果を電子密度の計算結値と比較した．得られた3‒ホルミル体から縮合，続く選択的還元によってトリプタミンアナローグの足がかりとなる3‒ニトロエチル体を得ることができた．\n結論：ベンズ[ f ] インドール骨格はインドールとアントラセンとのハイブリッド構造であり，求電子置換反応に対する反応性は，両者の性質を反映していることが判明した．", "subitem_description_type": "Other"}]}, "item_10001_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "1898", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Munakata, Tatsuo"}]}, {"nameIdentifiers": [{"nameIdentifier": "1899", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Watanabe, Toshiko"}]}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "国際医療福祉大学学会"}]}, "item_10001_radio_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_radio_item": "publisher"}]}, "item_10001_source_id_11": {"attribute_name": "書誌レコードID（NCID）", "attribute_value_mlt": [{"subitem_source_identifier": "AA12537130", "subitem_source_identifier_type": "NCID"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "21863652", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nyo Mi Swe"}, {"creatorName": "ニョ　ミ　スエ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "1867", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "宗像, 達夫"}, {"creatorName": "ムナカタ, タツオ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "1896", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "渡邊, 敏子"}, {"creatorName": "ワタナベ, トシコ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "1897", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-11-15"}], "displaytype": "simple", "download_preview_message": "", "file_order": 0, "filename": "22_2(46-52p).pdf", "filesize": [{"value": "549.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 549000.0, "url": {"label": "本文(PDF)", "url": "https://iuhw.repo.nii.ac.jp/record/865/files/22_2(46-52p).pdf"}, "version_id": "d838b800-96a2-4e8e-96fc-88d8cbcadf36"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "ベンズ[ f ] インドール", "subitem_subject_scheme": "Other"}, {"subitem_subject": "求電子置換反応", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Friedel-Crafts アシル化", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Vilsmeier ホルミル化", "subitem_subject_scheme": "Other"}, {"subitem_subject": "電子密度", "subitem_subject_scheme": "Other"}, {"subitem_subject": "benz[ f ]indole", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "electrophilic substitution", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Friedel-Crafts acylation", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Vilsmeier formylation", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "electron density", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "ベンズ[ f ]インドール‒2‒カルボン酸エチルの求電子置換反応における反応性と位置選択性", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "ベンズ[ f ]インドール‒2‒カルボン酸エチルの求電子置換反応における反応性と位置選択性"}, {"subitem_title": "Reactivity and regioselectivity of ethyl 1H-benz[f]indole-2-carboxylate in electrophilic substitution", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "15", "path": ["136"], "permalink_uri": "https://iuhw.repo.nii.ac.jp/records/865", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-11-15"}, "publish_date": "2017-11-15", "publish_status": "0", "recid": "865", "relation": {}, "relation_version_is_last": true, "title": ["ベンズ[ f ]インドール‒2‒カルボン酸エチルの求電子置換反応における反応性と位置選択性"], "weko_shared_id": -1}