{"created":"2023-05-15T09:17:53.525042+00:00","id":960,"links":{},"metadata":{"_buckets":{"deposit":"dfa5cb43-6f0c-467d-86f9-6c55203d7fb7"},"_deposit":{"created_by":15,"id":"960","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"960"},"status":"published"},"_oai":{"id":"oai:iuhw.repo.nii.ac.jp:00000960","sets":["2:142"]},"author_link":["2142","1951","613","112","611","610","2140","1950","1953","614","2139","2141","1955","1674"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"44","bibliographicPageStart":"33","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"国際医療福祉大学学会誌"},{"bibliographic_title":"Journal of the International University of Health and Welfare","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Recently, the effectiveness of various nutrients or food components on dementia has received considerable attention as a part of complementary and alternative medicine. The present study examined whether a docosahexaenoic acid-phosphatidylserine complex (DHA-PS) could improve learning and memory impairment in a scopolamine-induced amnesia model in mice. The results showed that DHA-PS improved learning and memory better than either DHA or PS alone. Under the conditions at which DHA-PS improved learning and memory, notable changes in mRNA levels of acetylcholine synthase, vesicular acetylcholine transporter and various muscarinic receptor subtypes in the hippocampus were not observed. These results suggest that, although the detailed mechanism of the improvement of learning and memory is not yet clear, DHA-PS may be useful for the development of new preventive and therapeutic methods for dementia.","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"近年，補完代替医療の一環として，認知症に対する各種栄養素あるいは食品成分の有用性が注目されている．本研究では，スコポラミン誘発健忘モデルマウスを用いて，ドコサヘキサエン酸-ホスファチジルセリン複合体（DHA-PS）製剤の学習記憶改善効果について検討した．その結果，DHA-PS 製剤が，ドコサヘキサエン酸（DHA）製剤やホスファチジルセリン（PS）製剤よりも優れた学習記憶改善効果を有することが明らかとなった．しかしながら，DHA-PS 製剤が学習記憶改善効果を示す条件において，海馬におけるアセチルコリン合成酵素，小胞体アセチルコリントランスポーターおよび各種ムスカリン受容体サブタイプのmRNA 発現量に特筆すべき変化は認められなかった．これらの結果より，詳細な作用メカニズムは未だ明らかでないものの，DHA-PS 製剤が認知症に対する新たな予防および治療法開発の一助となる可能性が示唆された．","subitem_description_type":"Other"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"Mochida-Saito, Atsumi"}]},{"nameIdentifiers":[{}],"names":[{"name":"Miyagawa, Kazuya"}]},{"nameIdentifiers":[{}],"names":[{"name":"Miyagishi, Hiroko"}]},{"nameIdentifiers":[{}],"names":[{"name":"Kurokawa, Kazuhiro"}]},{"nameIdentifiers":[{}],"names":[{"name":"Kimijima, Hidenao"}]},{"nameIdentifiers":[{}],"names":[{"name":"Tsuji, Minoru"}]},{"nameIdentifiers":[{}],"names":[{"name":"Takeda, Hiroshi"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"国際医療福祉大学学会"}]},"item_10001_radio_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_radio_item":"publisher"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"21863652","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"持田（齋藤）, 淳美"},{"creatorName":"モチダ（サイトウ）, アツミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"宮川, 和也"},{"creatorName":"ミヤガワ, カズヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"宮岸, 寛子"},{"creatorName":"ミヤギシ, ヒロコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"黒川, 和宏"},{"creatorName":"クロカワ, カズヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"君島, 秀尚"},{"creatorName":"キミジマ, ヒデナオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"辻, 稔"},{"creatorName":"ツジ, ミノル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"武田, 弘志"},{"creatorName":"タケダ, ヒロシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-04"}],"displaytype":"simple","filename":"24_1(33-44p).pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"本文(PDF)","url":"https://iuhw.repo.nii.ac.jp/record/960/files/24_1(33-44p).pdf"},"version_id":"b5f8d818-0194-4577-878c-8c21684ea150"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"DHA-PS","subitem_subject_scheme":"Other"},{"subitem_subject":"学習記憶","subitem_subject_scheme":"Other"},{"subitem_subject":"アセチルコリン","subitem_subject_scheme":"Other"},{"subitem_subject":"認知症","subitem_subject_scheme":"Other"},{"subitem_subject":"マウス","subitem_subject_scheme":"Other"},{"subitem_subject":"DHA-PS","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"learning and memory","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"acetylcholine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"dementia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mice","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"スコポラミン誘発健忘モデルマウスにおけるドコサヘキサエン酸‒ホスファチジルセリン複合体製剤の学習記憶改善効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"スコポラミン誘発健忘モデルマウスにおけるドコサヘキサエン酸‒ホスファチジルセリン複合体製剤の学習記憶改善効果"},{"subitem_title":"Improvement of learning and memory impairment by a docosahexaenoic acid-phosphatidylserine complex in a scopolamine-induced amnesia model in mice","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["142"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-04"},"publish_date":"2019-04-04","publish_status":"0","recid":"960","relation_version_is_last":true,"title":["スコポラミン誘発健忘モデルマウスにおけるドコサヘキサエン酸‒ホスファチジルセリン複合体製剤の学習記憶改善効果"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-21T10:39:49.894318+00:00"}