{"created":"2023-05-15T09:17:50.369125+00:00","id":876,"links":{},"metadata":{"_buckets":{"deposit":"c69ab6cd-7eb6-4764-886c-02b7566449ef"},"_deposit":{"created_by":15,"id":"876","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"876"},"status":"published"},"_oai":{"id":"oai:iuhw.repo.nii.ac.jp:00000876","sets":["2:137"]},"author_link":["1958","194","1614","1673","112","611","610","1951","1950","1954","1957","1953","1955","113","1956","1674"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"51","bibliographicPageStart":"44","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"国際医療福祉大学学会誌"},{"bibliographic_title":"Journal of the International University of Health and Welfare","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Although Kir6.2, a pore-forming subunit of ATP-sensitive potassium (KATP) channels, is highly expressed in brain regions　such as the hippocampus, hypothalamus and pituitary, which play important roles in stress responses, the mechanisms that　underlie the impact of Kir6.2 on stress responses are not yet fully understood. To clarify the role of Kir6.2 in stress responses, in the present study, we investigated the changes in serum corticosterone levels induced by acute restraint stress in Kir6.2－/－ mice. In the non-stressed condition, basal corticosterone levels in Kir6.2－/－ mice were higher than those in WT mice. Kir6.2－/－ mice also showed greater increases in serum corticosterone levels in response to exposure to acute restraint stress. Interestingly, these phenomena were more prominent in females than in males. The hippocampus regulates the endocrine stress system by modulating hypothalamic paraventricular nucleus activity. Chronic dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in response to stress is associated with impaired glucocorticoid function and inhibition of negative feedback via the glucocorticoid receptor (GR). Therefore, we next investigated whether Kir6.2 is expressed on GR-positive cells in hippocampal CA1 and DG. Immunohistochemical studies showed that Kir6.2 was co-localized with GR-positive cells in hippocampal CA1 and DG. These results suggest that Kir6.2 in GR-positive cells could play a key role in stress responses via the HPA axis.","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"ATP 感受性（KATP）カリウムチャネルのサブユニットのひとつであるKir6.2 は，脳内に広く存在しているが，特に，ストレス応答に重要な脳部位に豊富に存在しており，Kir6.2 がストレス応答に関与している可能性が示唆される．本研究では，Kir6.2 をコードする遺伝子（KCNJ11）を標的破壊して得られたKir6.2－/－マウスを用いることにより，Kir6.2 のストレス応答における役割について検討を行った．その結果，Kir6.2－/－マウスへの急性拘束ストレス刺激負荷により血中コルチコステロン濃度は上昇するが，その値は，ストレス下のC57BL/6J 野生型マウスより高値であった．また，Kir6.2 は，海馬CA1 および歯状回領域におけるグルココルチコイド受容体（GR）陽性細胞上に発現していることを確認した．これらの結果より，Kir6.2 が，視床下部-下垂体-副腎（hypothalamicpituitary-adrenal; HPA）系を介したストレス応答に関与していることが示唆された．","subitem_description_type":"Other"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"Saito, Atsumi"}]},{"nameIdentifiers":[{}],"names":[{"name":"Miyagawa, Kazuya"}]},{"nameIdentifiers":[{}],"names":[{"name":"Miyagishi, Hiroko"}]},{"nameIdentifiers":[{}],"names":[{"name":"Kurokawa, Kazuhiro"}]},{"nameIdentifiers":[{}],"names":[{"name":"Umeda, Akira "}]},{"nameIdentifiers":[{}],"names":[{"name":"Okada, Yasumasa"}]},{"nameIdentifiers":[{}],"names":[{"name":"Tsuji, Minoru"}]},{"nameIdentifiers":[{}],"names":[{"name":"Takeda, Hiroshi"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"国際医療福祉大学学会"}]},"item_10001_radio_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_radio_item":"publisher"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID（NCID）","attribute_value_mlt":[{"subitem_source_identifier":"AA12537130","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"21863652","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"齋藤, 淳美"},{"creatorName":"サイトウ, アツミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"宮川, 和也"},{"creatorName":"ミヤガワ, カズヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"宮岸, 寛子"},{"creatorName":"ミヤギシ, ヒロコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"黒川, 和宏"},{"creatorName":"クロカワ, カズヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"梅田, 啓"},{"creatorName":"ウメダ, アキラ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"岡田, 泰昌"},{"creatorName":"オカダ, ヤスマサ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"辻, 稔"},{"creatorName":"ツジ, ミノル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"武田, 弘志"},{"creatorName":"タケダ, ヒロシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-04-26"}],"displaytype":"detail","filename":"23_1(44-51p).pdf","filesize":[{"value":"2.5 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"本文(PDF)","url":"https://iuhw.repo.nii.ac.jp/record/876/files/23_1(44-51p).pdf"},"version_id":"f2f9ea44-c2f6-4fe0-8281-3b7e54a235ff"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ATP 感受性カリウムチャネル","subitem_subject_scheme":"Other"},{"subitem_subject":"ストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"HPA 系","subitem_subject_scheme":"Other"},{"subitem_subject":"グルココルチコイド","subitem_subject_scheme":"Other"},{"subitem_subject":"マウス","subitem_subject_scheme":"Other"},{"subitem_subject":"KATP channel","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HPA axis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"glucocorticoid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mice","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ATP 感受性カリウムチャネルKir6.2 のストレス応答における役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ATP 感受性カリウムチャネルKir6.2 のストレス応答における役割"},{"subitem_title":"Roles of KATP channels including Kir6.2 in stress responses","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["137"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-26"},"publish_date":"2018-04-26","publish_status":"0","recid":"876","relation_version_is_last":true,"title":["ATP 感受性カリウムチャネルKir6.2 のストレス応答における役割"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-21T10:40:58.606323+00:00"}