@article{oai:iuhw.repo.nii.ac.jp:00000874,
 author = {HTWE, Khin Moh Moh and 室井, 健三 and 丸山, 純人},
 issue = {1},
 journal = {国際医療福祉大学学会誌, Journal of the International University of Health and Welfare},
 month = {Mar},
 note = {Background and Purpose: Iron deposition in specific regions of the brain is found in multiple neurodegenerative diseases,including Parkinson’s disease (PD). The purpose of the study presented here was to estimate the susceptibility values of basal ganglia (BG) due to iron deposition using quantitative susceptibility mapping (QSM) in correlation with patients’ motor functions and to differentiate PD from normal controls.
Material and Methods: Twelve patients with PD, and 8 patients with essential tremor (ET) and other atypical parkinsonism (APS) and, 17 control subjects were recruited. QSM maps were generated from a conventional 3D gradient echo sequence using a 3T-MRI scanner. Susceptibility values (S-values) of anatomic regions of BG were measured on QSM images using Image J software.
Results: Among the deep gray matter nuclei, the mean normalized susceptibility values (Sn-values) of right substantia nigra pars compacta (SNpc), right dentate nucleus (DN), and right and left globus pallidus (GP) were determinant values for discrimination of the parkinsonian disorders from normal control. Moreover, the discriminative Sn-values in the right DN region were differentiating between PD and other APS. PD and ET group had obvious Sn-values’ difference in right GP region. In addition, the Sn-values differences in left DN and left GP were also usable in differentiation of PD from other APS.
Conclusion: QSM is a valuable tool for indirect quantification of iron deposition in deep gray matter nuclei, and right SNpc is the remarkable biomarker to distinguish PD from normal controls.},
 pages = {28--36},
 title = {Brain iron deposition analysis in Parkinson’s disease},
 volume = {23},
 year = {2018},
 yomi = {ムロイ, ケンゾウ and マルヤマ, スミト}
}