{"created":"2023-05-15T09:17:49.980976+00:00","id":866,"links":{},"metadata":{"_buckets":{"deposit":"472b37b7-8188-4828-92c9-1f73ed2f3cdb"},"_deposit":{"created_by":15,"id":"866","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"866"},"status":"published"},"_oai":{"id":"oai:iuhw.repo.nii.ac.jp:00000866","sets":["2:136"]},"author_link":["1900","1901"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-10-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"59","bibliographicPageStart":"53","bibliographicVolumeNumber":"22","bibliographic_titles":[{"bibliographic_title":"国際医療福祉大学学会誌"},{"bibliographic_title":"Journal of the International University of Health and Welfare","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Recent studies have shown that cancer cells surviving in a microenvironment characterized by hypoxia, a low pH, and a low glucose level have the ability to adapt to these adverse conditions. We measured the pH in the central tumor area of primary lung cancer, and evaluated its association with clinicopathological factors. There was a negative correlation between the tumor size and pH; with an increase in the tumor size, the pH decreased. In addition, pH in lung adenocarcinoma was negatively correlated with the expression of tumor markers, although the correlation was not significant. Cancer cells grow at a markedly low pH compared with the physiological environment. There is a possibility that this low pH is a microenvironment that is appropriate rather than adverse for the proliferative ability of cancer cells.","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Recent studies have shown that cancer cells surviving in a microenvironment characterized by hypoxia, a low pH, and a low glucose level have the ability to adapt to these adverse conditions. We measured the pH in the central tumor area of primary lung cancer, and evaluated its association with clinicopathological factors. There was a negative correlation between the tumor size and pH; with an increase in the tumor size, the pH decreased. In addition, pH in lung adenocarcinoma was negatively correlated with the expression of tumor markers, although the correlation was not significant. Cancer cells grow at a markedly low pH compared with the physiological environment. There is a possibility that this low pH is a microenvironment that is appropriate rather than adverse for the proliferative ability of cancer cells.","subitem_description_type":"Other"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"Sawada, Takahiro"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"国際医療福祉大学学会"}]},"item_10001_radio_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_radio_item":"publisher"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID（NCID）","attribute_value_mlt":[{"subitem_source_identifier":"AA12537130","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"21863652","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"澤田, 貴裕"},{"creatorName":"サワダ, タカヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-15"}],"displaytype":"simple","filename":"22_2(53-59p).pdf","filesize":[{"value":"418.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"本文(PDF)","url":"https://iuhw.repo.nii.ac.jp/record/866/files/22_2(53-59p).pdf"},"version_id":"ce6b96bb-216f-4586-a08d-dbb07b3d650c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"水素イオン指数","subitem_subject_scheme":"Other"},{"subitem_subject":"微小環境","subitem_subject_scheme":"Other"},{"subitem_subject":"低酸素誘導性因子","subitem_subject_scheme":"Other"},{"subitem_subject":"hydrogen ion exponent","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"microenvironment","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hypoxia-inducble factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Association between the pH and clinicopathological characteristics of lung cancer tissue","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association between the pH and clinicopathological characteristics of lung cancer tissue"},{"subitem_title":"Association between the pH and clinicopathological characteristics of lung cancer tissue","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["136"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-15"},"publish_date":"2017-11-15","publish_status":"0","recid":"866","relation_version_is_last":true,"title":["Association between the pH and clinicopathological characteristics of lung cancer tissue"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-21T10:41:26.145862+00:00"}