{"created":"2023-05-15T09:17:17.469859+00:00","id":8,"links":{},"metadata":{"_buckets":{"deposit":"4a1ffe4c-8a32-48a3-97ca-8346edf3b00e"},"_deposit":{"created_by":15,"id":"8","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8"},"status":"published"},"_oai":{"id":"oai:iuhw.repo.nii.ac.jp:00000008","sets":["1:31"]},"author_link":["548","186","547","182","546","184"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-08-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"33","bibliographicPageStart":"24","bibliographicVolumeNumber":"16","bibliographic_titles":[{"bibliographic_title":"国際医療福祉大学紀要"},{"bibliographic_title":"Bulletin of International University of Health and Welfare","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"真核生物にはD体のアミノ酸は存在しないというのが長い間の定説であったが,分析機器・技法の開発・改良によりD体のアミノ酸が高等動物にも豊富に存在していることが明らかになってきた。1992年には哺乳類の脳に多量のD-セリンが発見された。しかし,そのD-セリンの由来は長い間、不明であった。1999年になり、ようやくD-セリンをL-セリンから合成する酵素であるセリンラセマーゼが哺乳類の脳で発見された。D-セリンは神経伝達において重要な役割を担い,統合失調症などの様々な精神疾患に関与しているとする報告が数多くなされたことから、セリンラセマーゼは注目を集め、精力的な研究が行われている。そこで、セリンラセマーゼと疾患について最近の研究をまとめた。","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"It was long thought that D-amino acids are not present in eukaryotes, but the development and improvement of analytical instruments and procedures have led to the discovery that D-amino acids are abundant even in higher animals. A large amount of D-serine was found in mammalian brains in 1992, but the origin of this D-serine remained unknown until 1999, when serine racemase (which synthesizes D-serine from L-serine) was identified in mammalian brains. Since many studies have shown that D-serine plays an important role in neurotransmission and is involved in various psychiatric diseases, serine racemase has been attracting great attention and is being intensively studied. We have therefore reviewed recent progress made in serine racemase and disease.","subitem_description_type":"Other"}]},"item_10002_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"Maruyama, Rindo"}]},{"nameIdentifiers":[{}],"names":[{"name":"Ohide, Hiroko"}]},{"nameIdentifiers":[{}],"names":[{"name":"Konno, Ryuichi"}]}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"国際医療福祉大学"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13424661","subitem_source_identifier_type":"ISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{},{}],"nameIdentifiers":[{}]},{"creatorNames":[{},{}],"nameIdentifiers":[{}]},{"creatorNames":[{},{}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-05-24"}],"displaytype":"simple","filename":"16(24-33p).pdf","filesize":[{"value":"675.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"本文(PDF)","url":"https://iuhw.repo.nii.ac.jp/record/8/files/16(24-33p).pdf"},"version_id":"3a6716ba-88e6-49c2-88a2-17c6b9ee5f03"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"セリンラセマーゼ","subitem_subject_scheme":"Other"},{"subitem_subject":"D-セリン","subitem_subject_scheme":"Other"},{"subitem_subject":"NMDA受容体","subitem_subject_scheme":"Other"},{"subitem_subject":"Serine racemase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"D-Serine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NMDA receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"セリンラセマーゼと疾患","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"セリンラセマーゼと疾患"},{"subitem_title":"Serine Racemase and Disease","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"15","path":["31"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-05-07"},"publish_date":"2012-05-07","publish_status":"0","recid":"8","relation_version_is_last":true,"title":["セリンラセマーゼと疾患"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-05-15T09:35:52.307417+00:00"}