{"created":"2023-05-15T09:17:44.327220+00:00","id":738,"links":{},"metadata":{"_buckets":{"deposit":"5eb1b264-ebfd-4305-bdb4-019b52065e3d"},"_deposit":{"created_by":15,"id":"738","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"738"},"status":"published"},"_oai":{"id":"oai:iuhw.repo.nii.ac.jp:00000738","sets":["2:128"]},"author_link":["1673","611","610","1672","1674"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"81","bibliographicPageStart":"75","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"国際医療福祉大学学会誌"},{"bibliographic_title":"Journal of the International University of Health and Welfare","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In the present study, we investigated the association between chronic neuropathic pain and the ability to adapt to stress.Animal model of chronic neuropathic pain was generated in mice by partial sciatic nerve injury. The results demonstratedthat a single exposure to restraint stress for 60 min produced a decrease in head-dipping behavior in naive mice, whichhad not been subjected to chronic neuropathic pain by partial sciatic nerve injury, in the hole-board test, and these acuteemotional responses were recovered by exposure to restraint stress for 60 min/day for 14 days. However, mice that weresubjected to chronic neuropathic pain for 4 weeks continued to show a decrease in head-dipping behavior in the hole-boardtest after exposure to restraint stress for 60 min/day for 14 days. These results indicate that chronic neuropathic pain impairsthe ability to adapt to stress. Additionally, the present study tried to clarify the effect of the selective serotonin reuptakeinhibitor paroxetine on neuropathic pain. The results demonstrated that repeated administration of paroxetine produced asignificant reduction in tactile allodynia in von Frey test. This suggests that paroxetine might be useful for the treatment ofadjustment disorder in patients with neuropathic pain.","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本研究では,神経障害性慢性疼痛モデルマウスを作製し,本モデルマウスのストレス適応能力について行動学的に検討した.神経障害性慢性疼痛モデルマウスは,右後肢坐骨神経を半周結紮することで作製した.Holeboard試験において,1 時間の拘束ストレス刺激により惹起される情動性の低下は,同ストレス刺激を1 日1 回14 日間慢性的に負荷した非結紮群においては消失し,ストレス適応が形成された.一方,結紮群においては情動性の低下が依然認められ,神経障害性慢性疼痛によりストレス適応形成の障害が惹起されることが示唆された.さらに本研究では,神経障害性疼痛に対するパロキセチンの除痛効果についても検討した.その結果,坐骨神経結紮により惹起されるアロディニア反応は,パロキセチンを結紮翌日から慢性投与することで有意に抑制され,疼痛コントロールに難渋する神経障害性疼痛に対するパロキセチンの有効性が示された.したがって,神経障害性疼痛を有する患者が呈する適応障害に対しても,パロキセチンが有効である可能性が示唆される.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"国際医療福祉大学学会"}]},"item_10001_radio_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_radio_item":"publisher"}]},"item_10001_relation_12":{"attribute_name":"NII論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"110010022321"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"CiNii"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://ci.nii.ac.jp/naid/110010022321","subitem_relation_type_select":"URI"}}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID（NCID）","attribute_value_mlt":[{"subitem_source_identifier":"AA12537130","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"21863652","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石井, 大輔"},{"creatorName":"イシイ, ダイスケ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"宮川, 和也"},{"creatorName":"ミヤガワ, カズヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"齋藤, 淳美"},{"creatorName":"サイトウ, アツミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"辻, 稔"},{"creatorName":"ツジ, ミノル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"武田, 弘志"},{"creatorName":"タケダ, ヒロシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-04-26"}],"displaytype":"simple","filename":"21_1(75-81p).pdf","filesize":[{"value":"640.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"本文(PDF)","url":"https://iuhw.repo.nii.ac.jp/record/738/files/21_1(75-81p).pdf"},"version_id":"949ee790-b806-46b1-b6b8-f7d122a4d7a3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ストレス適応神経障害性慢性疼痛","subitem_subject_scheme":"Other"},{"subitem_subject":"マウス","subitem_subject_scheme":"Other"},{"subitem_subject":"パロキセチン","subitem_subject_scheme":"Other"},{"subitem_subject":"stress adaptation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chronic neuropathic pain","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mice, paroxetine","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"神経障害性慢性疼痛が惹起するストレス適応形成障害とパロキセチンの除痛効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"神経障害性慢性疼痛が惹起するストレス適応形成障害とパロキセチンの除痛効果"},{"subitem_title":"Maladaptation to stress as a result of chronic neuropathic pain and the antinociceptive effect of paroxetine","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["128"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-04-26"},"publish_date":"2016-04-26","publish_status":"0","recid":"738","relation_version_is_last":true,"title":["神経障害性慢性疼痛が惹起するストレス適応形成障害とパロキセチンの除痛効果"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-21T10:43:02.947129+00:00"}