{"created":"2023-05-15T09:17:23.163996+00:00","id":146,"links":{},"metadata":{"_buckets":{"deposit":"c376e70a-73a5-4bce-b779-34158590cb78"},"_deposit":{"created_by":15,"id":"146","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"146"},"status":"published"},"_oai":{"id":"oai:iuhw.repo.nii.ac.jp:00000146","sets":["1:13"]},"author_link":["830","828"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000-12-22","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"14","bibliographicPageStart":"7","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"国際医療福祉大学紀要"},{"bibliographic_title":"Bulletin of International University of Health and Welfare","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"高齢化に伴う痴呆症の増加は深刻な社会問題となり、特に変性型痴呆、とくにアルツハイマー病に関しては、病因、治療法ともにいまだ不明なことが多過ぎる。本総説では著者自身の研究を含めて、先端領域に至る研究上の問題点を指摘した。アルツハイマー病の形態学的時系列で明らかになった老人斑や神経原線維変化の問題を、その細胞障害の帰着点であるニューロン死の問題でとりあげ、さらに発症に関係する遺伝子を家族性、孤発性両面により追求した。しかし、中核症状である痴呆がどの病変に関係するのか?、アミロイド形成とPHF形成は本当に相互に関係するのか?PHFを有する細胞数で細胞死を納得できるか?もっとも通常の晩発型孤発型アルツハイマー病のアミロイド形成は家族性アルツハイマー病同様A-β42分泌と関係があるとすると、apoEは異常蓄積物形成のメカニズムとどのようにかかわりあっているのか?よく分かっていない。","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"This general consideration focused on the aging process of human brain, especially on the recent advance of study of Alzheimer's diseases. Problems of death of neurons reached from various developmental stage of cell damages occurred in an intra-and an extra-neuronal molecular changes were demonstrated. Problems of appearances of neurofibrillary tangles and senile plaques in pathological process of aged human brains were discussed. In conclusion, genes attacked with Alzheimer's diseases were pointed out in molecular genetics. Molecular-biological cascade stated from beta-amyloid deposits arrived tau-protein formed PHF, finally neuronal death, still remained unsolved.","subitem_description_type":"Other"}]},"item_10002_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"SHIMADA, Hiroyuki"}]}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"国際医療福祉大学"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN1059280X","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13424661","subitem_source_identifier_type":"ISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{},{}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-06-28"}],"displaytype":"simple","filename":"5(7-14p).pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"本文(PDF)","url":"https://iuhw.repo.nii.ac.jp/record/146/files/5(7-14p).pdf"},"version_id":"c334c444-a969-41b6-87b8-aaebd88fa153"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"脳の老化","subitem_subject_scheme":"Other"},{"subitem_subject":"アルツハイマー病","subitem_subject_scheme":"Other"},{"subitem_subject":"関連遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"Aging of Brain","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Alzheimer's disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Related genes","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ヒト脳の老化の諸問題;とくにアルツハイマー病について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト脳の老化の諸問題;とくにアルツハイマー病について"},{"subitem_title":"The aging process of the human brain ─ The resent advance of study alzheimer's disease","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"15","path":["13"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-06-07"},"publish_date":"2012-06-07","publish_status":"0","recid":"146","relation_version_is_last":true,"title":["ヒト脳の老化の諸問題;とくにアルツハイマー病について"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-05-15T09:29:01.740889+00:00"}