{"created":"2023-05-15T09:18:00.986233+00:00","id":1165,"links":{},"metadata":{"_buckets":{"deposit":"1e5bdf8b-2eff-425f-98f4-2472b917ff82"},"_deposit":{"created_by":15,"id":"1165","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"1165"},"status":"published"},"_oai":{"id":"oai:iuhw.repo.nii.ac.jp:00001165","sets":["2:151"]},"author_link":["2563","358","1985","1986","2564","1778","2565","367","1988","1989","2566","2567"],"control_number":"1165","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-10-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"23","bibliographicPageStart":"12","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"国際医療福祉大学学会誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of the International University of Health and Welfare","bibliographic_titleLang":"en"}]}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"目的：抗コリン作用を持つ医薬品の副作用リスクと PK/PD パラメータとの関連性を解析した．\n方法：抗コリン作用を持つ医薬品に関して，医薬品インタビューフォームから血中濃度（AUC，Cmax）および，各医薬品のムスカリン M3 受容体（M3R）に対する阻害定数（Ki）を調査した．血中濃度を Ki 値で除した PK/PD パラメータと，抗コリン作用による全副作用および器官別副作用の頻度との関連性を解析した．\n結果：血中濃度情報および副作用情報を収集できた医薬品は 39 製剤であった．そのうち，M3R に対する Ki 値が確認できた医薬品 15 製剤について，PK/PD パラメータと副作用頻度の関連性を検討したところ，AUC/Ki 値と全副作用頻度の間に中等度の相関性が認められた（r = 0.512，p = 0.061）．また，器官別副作用では，AUC/Ki 値と泌尿器の副作用頻度との間に中等度の相関性が認められた（r = 0.591，p = 0.026）．\n考察：M3R に対する阻害活性を示す PK/PD パラメータを用いることで，抗コリン作用による副作用リスクを評価しうる可能性を見出した．","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"ITO, Takeshi"}]},{"nameIdentifiers":[{}],"names":[{"name":"KATO, Yoshinori"}]},{"nameIdentifiers":[{}],"names":[{"name":"MAEZAWA, Kayoko"}]},{"nameIdentifiers":[{}],"names":[{"name":"SUGIYAMA, Natsuko"}]},{"nameIdentifiers":[{}],"names":[{"name":"KURAMOTO, Keiji"}]},{"nameIdentifiers":[{}],"names":[{"name":"MOMOSE, Yasuyuki"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"国際医療福祉大学学会","subitem_publisher_language":"ja"}]},"item_10001_radio_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_radio_item":"publisher","subitem_radio_language":"ja"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID（NCID）","attribute_value_mlt":[{"subitem_source_identifier":"AA12537130","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"21863652","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"伊東, 岳","creatorNameLang":"ja"},{"creatorName":"イトウ, タケシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"加藤, 芳徳","creatorNameLang":"ja"},{"creatorName":"カトウ, ヨシノリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"前澤, 佳代子","creatorNameLang":"ja"},{"creatorName":"マエザワ, カヨコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"杉山, 奈津子","creatorNameLang":"ja"},{"creatorName":"スギヤマ, ナツコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"倉本, 敬二","creatorNameLang":"ja"},{"creatorName":"クラモト, ケイジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"百瀬, 泰行","creatorNameLang":"ja"},{"creatorName":"モモセ, ヤスユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-10-22"}],"displaytype":"simple","filename":"26_2(12-23p).pdf","filesize":[{"value":"954.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"本文(PDF)","url":"https://iuhw.repo.nii.ac.jp/record/1165/files/26_2(12-23p).pdf"},"version_id":"fb7c4fd4-bbb4-46ca-8ee4-0407f964928a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"抗コリン作用","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"副作用リスク","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"薬物動態学 / 薬力学","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"阻害活性","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"anticholinergic effect","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"risk of side effect","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pharmacokinetics/pharmacodynamics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"inhibitory activity","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"抗コリン作用を示す医薬品の副作用リスクと PK/PD パラメータとの関連性に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"抗コリン作用を示す医薬品の副作用リスクと PK/PD パラメータとの関連性に関する研究","subitem_title_language":"ja"},{"subitem_title":"Study on the relationship between the risk of side effects of drugs with anticholinergic activity and PK/PD parameters","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["151"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-10-22"},"publish_date":"2021-10-22","publish_status":"0","recid":"1165","relation_version_is_last":true,"title":["抗コリン作用を示す医薬品の副作用リスクと PK/PD パラメータとの関連性に関する研究"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-07-10T01:09:38.169847+00:00"}