{"created":"2023-05-15T09:17:59.233319+00:00","id":1112,"links":{},"metadata":{"_buckets":{"deposit":"7367033a-e651-4828-bdf8-949ac583185c"},"_deposit":{"created_by":15,"id":"1112","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"1112"},"status":"published"},"_oai":{"id":"oai:iuhw.repo.nii.ac.jp:00001112","sets":["2:148"]},"author_link":["2400","164","2401","165"],"control_number":"1112","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-02-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"112","bibliographicPageStart":"99","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"国際医療福祉大学学会誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of the International University of Health and Welfare","bibliographic_titleLang":"en"}]}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"近年,有害事象の自発報告システム(Spontaneous Reporting System : SRS)による医薬品副作用情報データベー スを活用した研究が増加してきている.そこで今回,直接作用型経口抗凝固薬(Direct oral anticoagulants :DOAC)に関する SRS を活用した研究論文を収集し系統的レビューを行うことを計画した.PubMed と医中誌においてデータベース検索により,FAERS と JADER の抗凝固薬に関する論文の検索を実施し,タイトルおよび抄録などから条件に合う論文を選択した.条件を満たす論文は 15 報あり報告は増加してきていた.シグナル検出として,ROR,PRR,EBGM,IC が用いられていた.DOAC の有害事象として,出血に関連する論文が 11 報と最も多く,すべてシグナルが検出され,女性と高齢者でリスクが上昇する傾向が見られた.転帰が死亡となる分析を含む論文は 4 報であった.同じ薬剤であっても研究に使用する SRS データベースの報告の時期と期間により結果に影響を及ぼすため,薬剤の安全性評価には報告の時期と期間を考慮する必要があった.今後,SRS を活用したさらに多くの研究がなされることは,DOAC の安全性の評価のために有用であると考えられる.","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10001_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"NISHIZUKA, Norihito"}]},{"nameIdentifiers":[{}],"names":[{"name":"IKEDA, Shunya"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"国際医療福祉大学学会","subitem_publisher_language":"ja"}]},"item_10001_radio_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_radio_item":"publisher","subitem_radio_language":"ja"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID（NCID）","attribute_value_mlt":[{"subitem_source_identifier":"AA12537130","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"21863652","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"西塚, 典仁","creatorNameLang":"ja"},{"creatorName":"ニシヅカ, ノリヒト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"池田, 俊也","creatorNameLang":"ja"},{"creatorName":"イケダ, シュンヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-03-03"}],"displaytype":"simple","filename":"26_1(99-112p).pdf","filesize":[{"value":"689.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"本文(PDF)","url":"https://iuhw.repo.nii.ac.jp/record/1112/files/26_1(99-112p).pdf"},"version_id":"816621e6-1520-4340-beb1-46f166b1ae4f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"直接作用型経口抗凝固薬","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"有害事象","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"自発報告システム","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"系統的レビュー","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"direct oral anticoagulants","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"adverse event","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"spontaneous reporting system","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"systematic review","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"直接作用型経口抗凝固薬を対象とした医薬品副作用情報データベース研究の系統的レビュー","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"直接作用型経口抗凝固薬を対象とした医薬品副作用情報データベース研究の系統的レビュー","subitem_title_language":"ja"},{"subitem_title":"A systematic review of direct oral anticoagulant-induced adverse events using adverse event databases","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["148"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-03-03"},"publish_date":"2021-03-03","publish_status":"0","recid":"1112","relation_version_is_last":true,"title":["直接作用型経口抗凝固薬を対象とした医薬品副作用情報データベース研究の系統的レビュー"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-07-13T02:16:33.843800+00:00"}