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Repeated treatment with yokukansan, a traditional Japanese herbal medicine, suppresses the increase in the conditioned fear response induced by sigma1 (σ1) receptor agonist in mice
https://iuhw.repo.nii.ac.jp/records/875
https://iuhw.repo.nii.ac.jp/records/8758a26e8f6-bb3c-4c3c-8e81-8e95996f0d7f
名前 / ファイル | ライセンス | アクション |
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本文(PDF) (490.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-04-26 | |||||
タイトル | ||||||
タイトル | Repeated treatment with yokukansan, a traditional Japanese herbal medicine, suppresses the increase in the conditioned fear response induced by sigma1 (σ1) receptor agonist in mice | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Repeated treatment with yokukansan, a traditional Japanese herbal medicine, suppresses the increase in the conditioned fear response induced by sigma1 (σ1) receptor agonist in mice | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 抑肝散 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | フルボキサミン | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 文脈的恐怖条件付け | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 抗不安効果 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | σ1 受容体 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | マウス | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | yokukansan | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | fluvoxamine | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | contextual fear conditioning | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | anxiolytic effect | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | σ1 receptor | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | mouse | |||||
著者 |
大野, 凜太郎
× 大野, 凜太郎× 宮岸, 寛子× 辻, 稔× 齋藤, 淳美× 宮川, 和也× 黒川, 和宏× 武田, 弘志 |
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著者別名 | ||||||
姓名 | Ohno, Rintaro | |||||
著者別名 | ||||||
姓名 | Miyagishi, Hiroko | |||||
著者別名 | ||||||
姓名 | TSUJI, Minoru | |||||
著者別名 | ||||||
姓名 | Saito, Atsumi | |||||
著者別名 | ||||||
姓名 | Miyagawa, Kazuya | |||||
著者別名 | ||||||
姓名 | Kurokawa, Kazuhiro | |||||
著者別名 | ||||||
姓名 | Takeda, Hiroshi | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Yokukansan is a traditional Japanese herbal medicine that has been reported to improve stress-related psychiatric symptoms such as anxiety. Recently, we found that repeated treatment with yokukansan synergistically enhances the anxiolytic-like effect of fluvoxamine, an antidepressant that preferentially activates brain 5-HT neurotransmission, in the contextual fear conditioning paradigm in mice. A growing body of evidence indicates that fluvoxamine has affinity for and acts as an agonist for sigma1 (σ1) receptor. Therefore, the present study examined whether σ1 receptor plays a role in the enhancing effect of yokukansan on the anxiolytic-like effect of fluvoxamine in mice, as estimated by the contextual fear conditioning paradigm. A single administration of SA4503 (1 mg/kg, i.p.), a selective σ1 receptor agonist, before the test session significantly enhanced freezing behavior in mice. In a combination study, the enhancing effect of SA4503 (1 mg/kg,i.p.) on freezing behavior was significantly attenuated in mice that had been repeatedly pretreated with yokukansan (1 g/kg, p.o.) once a day for 6 days after the conditioning session. These results indicate that chronic treatment with yokukansan downregulates σ1 receptor-mediated signaling, which positively modulates the conditioned fear response, and this may be related, at least in part, to the mechanism of the synergistic interaction between yokukansan and fluvoxamine regarding anxiety. | |||||
書誌情報 |
国際医療福祉大学学会誌 en : Journal of the International University of Health and Welfare 巻 23, 号 1, p. 37-43, 発行日 2018-03-31 |
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出版者 | ||||||
出版者 | 国際医療福祉大学学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 21863652 | |||||
書誌レコードID(NCID) | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12537130 | |||||
著者版フラグ | ||||||
値 | publisher |