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Determination of sofosbuvir via a high-performance liquid chromatography method using ultraviolet detection
https://iuhw.repo.nii.ac.jp/records/885
https://iuhw.repo.nii.ac.jp/records/8853afc3e06-713c-425d-8bb3-e960278cdfe3
名前 / ファイル | ライセンス | アクション |
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本文(PDF) (346.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-04-27 | |||||
タイトル | ||||||
タイトル | Determination of sofosbuvir via a high-performance liquid chromatography method using ultraviolet detection | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Determination of sofosbuvir via a high-performance liquid chromatography method using ultraviolet detection | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | sofosbubir | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hepatitis C virus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HPLC | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | UV detection | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | sofosbuvir | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | C 型肝炎ウイルス | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | HPLC | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | UV 検出 | |||||
著者 |
Su, Nwe San
× Su, Nwe San× 松本, 准× 小池, 雅子× 斎藤, 祐実× 坂上, 弘明× 加藤, 芳徳× 有吉, 範高× 山田, 治美 |
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著者別名 | ||||||
姓名 | Su, Nwe San | |||||
著者別名 | ||||||
姓名 | Matsumoto, Jun | |||||
著者別名 | ||||||
姓名 | Koike, Masako | |||||
著者別名 | ||||||
姓名 | Saito, Yumi | |||||
著者別名 | ||||||
姓名 | Sakaue, Hiroaki | |||||
著者別名 | ||||||
姓名 | Kato, Yoshinori | |||||
著者別名 | ||||||
姓名 | Ariyoshi, Noritaka | |||||
著者別名 | ||||||
姓名 | Yamada, Harumi | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Sofosbuvir (SOF) is a nucleotide analog drug that inhibits hepatitis C virus replication. In the present study, we aimed todevelop a simple, specific, sensitive, and precise method for the quantification of SOF in water-based and human plasmasamples by using a high-performance liquid chromatography method with ultraviolet detection (HPLC-UV). The analyte wasextracted from 0.25 mL water or human plasma samples with an acetonitrile-based solution and analyzed on a C18 reversedphasecolumn. Sorafenib was used as an internal standard (IS). The mobile phase was composed of ammonium acetatebuffer, and methanol and acetonitrile. The flow rate was 1.0 mL/min, and the UV wavelength was set at 265 nm. Theretention times of SOF and IS were 7.8 min and 9.1 min, respectively. The total run time for a single analysis was 15.0 min.The calibration curve was linear within the range 0.1-10.0 μg/mL. The limit of quantitation was 0.1 μg/mL. The recovery ofthe drug from human plasma samples was greater than 99 %. The intra- and inter-day precision of water-based and plasmasamples ranged from 1.41% to 10.06% and 0.21 to 6.53%, respectively. The intra- and inter-day accuracy of water-based andplasma samples ranged from 92.71 to 98.41% and 89.31 to 101.21%, respectively. The proposed method is very simple andallows acquiring a good recovery of the analytes. The developed HPLC-UV method may be applied to conductingpharmacokinetic studies in the determination of SOF. | |||||
書誌情報 |
国際医療福祉大学学会誌 en : Journal of the International University of Health and Welfare 巻 23, 号 1, p. 130-136, 発行日 2018-03-31 |
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出版者 | ||||||
出版者 | 国際医療福祉大学学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 21863652 | |||||
書誌レコードID(NCID) | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12537130 | |||||
著者版フラグ | ||||||
値 | publisher |